College of Health and Human Services
George Mason University
George Mason University Mason
George Mason University

Germaine Louis, PhD, MS

Dean, College of Health and Human Services

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Biography

Dr. Germaine Louis is an internationally recognized reproductive and perinatal epidemiologist whose expertise focuses on the impact of environmental influences on human fecundity and fertility. Her research has addressed a mixture of environmental exposures, including endocrine disruptors, stress, diet, and physical activity in relation to a spectrum of reproductive outcomes in both men and women. In addition, Dr. Louis’ research extends to studies of the implications of fecundity and fertility for health across the lifespan and future generations. A complimentary and parallel avenue of research includes methods aimed at addressing challenges, such as the complexity associated with studying exposure mixtures and studying reproductive potential outcomes that often are not statistically independent or may be blocked by an intervening event. She was an early pioneer in the application of the exposome research paradigm for understanding environmental influences on human fecundity and fertility impairments. She has served as Principal Investigator for original extramural and intramural research totaling over $53 million.

Prior to joining the College of Health and Human Services in October 2017, Dr. Louis was the Director for the Division of Intramural Population Health Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health where she led population health scientists in designing research aimed at enhancing the health and well-being of fetuses, pregnant women, children, and young adults. Prior to joining NICHD, Dr. Louis was a tenured professor in the Department of Social and Preventive Medicine, University of Buffalo, School of Medicine and Biomedical Sciences, where she taught in both the graduate and medical school programs, and led research focusing on the impact of environmental influences on human reproduction and development. She has published numerous scientific papers and technical reports, and co-edited the textbook Reproductive and Perinatal Epidemiology. She has provided considerable service to The National Academies, Pan American Health Organization, U.S. Environmental Protection Agency, and World Health Organization among other governmental agencies, as well as for her disciplinary home as elected President for the Society of Pediatric and Perinatal Epidemiologic Research and the Society for Epidemiologic Research, along with serving on the boards for the American College of Epidemiology and the International Society for Environmental Epidemiology. She is the recipient of many awards for research excellence, mentoring and service.

University Service

  • Member, Research and Scholarship Working Group, 2017-present

Degrees

PhD, Epidemiology, State University of New York at Buffalo

MS, Epidemiology, State University of New York at Buffalo

Personal Websites:

Research

Research Interests

  • Human reproduction and development
  • Environmental influences on human fecundity and fertility
  • Endocrine disruptors
  • Exposome
  • Research methods

Select 2017 Publications

Buck Louis GM, Bell E, Xie Y, Sundaram R, & Yeung E. Parental health and infant outcomes, Upstate KIDS Study. Fertility and Sterility. In Press.

Zhang C, Hediger ML, Albert PS, Grewal J, Sciscione A, Grobman WA, Wing DA, Newman RB, Wapner R, D’Alton ME, Skupski D, Nageotte MP, Ranzini AC, Owen J, Chien EK, Craigo S, Kim S, Grantz KL, Buck Louis GM. Association of maternal obesity with longitudinal ultrasonographic measures of fetal growth: findings from the NICHD Fetal Growth Studies – Singletons. JAMA Pediatrics. 2018;172(1):24-31. PMID: 29131898

Eisenberg ML, Sapra KJ, Kim S, Chen Z, Buck Louis GM. Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: data from the Longitudinal Investigation of Fertility and the Environment Study. Fertility and Sterility. 2017;108(4):613-619. PMID: 28863939

Smarr MM, Sapra KJ, Gemmill A, Kahn LG, Wise LA, Lynch CD, Factor-Litvak P, Mumford SL, Skakkebaek NE, Slama R, Lobdell DT, Stanford JB, Jensen TK, Boyle EH, Eisenberg ML, Turek PJ, Sundaram R, Thoma ME, Buck Louis GM. Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer. Human Reproduction. 2017;32(3):499-504. PMID: 28137753

Patel CJ, Sundaram R, Buck Louis GM. A data-driven search for semen-related phenotypes of impaired human fecundity. Andrology. 2017;5(1):95-102. PMCID: PMC5164952. PMID: 27792860

Buck Louis GM, Smarr M, Patel C. The exposome research paradigm: An opportunity to understand the basis for human health and disease. Current Environmental Health Reports. 2017;4(1):89-98. PMCID: PMC5363405. PMID: 28194614

Select Publications, 2012-2016

(Top 20) indicates the top 20 impact papers. * denotes mentee authored paper

Mumford SL, Sapra KJ, King RB, Louis JF, Buck Louis GM. Pregnancy intentions – A complex construct and call for new measures. Fertility and Sterility. 2016;106(6):1453-1462. PMCID: PMC5159192. PMID: 27490044

*Smarr MM, Grantz KL, Sundaram R, Maisog JM, Honda M, Kannan K, Buck Louis GM. Urinary paracetamol and time-to-pregnancy. Human Reproduction. 2016;31(9):2119-2127. PMCID: PMC4991660. PMID: 27412248

Yeung EH, Sundaram R, Bell EM, Druschel C, Kus C, Xie Y, Buck Louis GM. Infertility treatment and children’s longitudinal growth between birth and 3 years of age. Human Reproduction. 2016;31(7):1621-1628. PMCID: PMC4901884. PMID: 27165624 (Top 20)

Buck Louis GM, Backonja U, Schliep KC, Sun L, Peterson CM, Chen Z. Women's Reproductive History Before the Diagnosis of Incident Endometriosis. Journal of Women’s Health. 2016;25(10)1021-1029. PMCID: PMC5111831. PMID: 27379997

Grantz KL, Grewal J, Albert PS, Wapner R, D’Alton ME, Sciscone A, Grobman WA, Wing DA, Owen J, Newman RB, Chien EK, Gore-Langton RE, Kim S, Zhang C, Buck Louis GM, Hediger ML. Dichorionic Twin Trajectories: The NICHD Fetal Growth Studies. American Journal of Obstetrics and Gynecology. PMCID: PMC4967402. PMID: 27143399

Buck Louis GM, Sapra KJ, Schisterman EF, Lynch CD, Maisog JM, Grantz KL, Sundaram R. Lifestyle and pregnancy loss in a contemporary cohort of women recruited prior to conception: The LIFE Study.  Fertility and Sterility. 2016;106(1):180-188. PMCID: PMC4930884. PMID: 27016456 (Top 20)

Yeung EH, Buck Louis GM, Lawrence D, Kannan K, McLain AC, Caggana M, Druschel C, Bell E. Eliciting parental support for the use of newborn blood spots for population health research. BMC Medical Research Methodology. 2016;16:14. PMCID: PMC4741027. PMID: 26846420

*Sapra KJ, Buck Louis GM, Sundaram R, Joseph KS, Bates LM, Galea S, Ananth CV. Signs and symptoms associated with early pregnancy loss: Findings form a population-based preconception cohort.  Human Reproduction. 2016;31(4):887-896. PMCID: PMC4791918. PMID: 26936888

Yeung EH, Sundaram R, Bell EM, Druschel C, Kus C, Ghassabian A, Bello S, Xie Y, Buck Louis GM. Examining infertility treatment and early childhood development in the Upstate KIDS. JAMA Pediatrics. 2016;170(3):251-258. PMCID: PMC5000851. PMID: 26746435 (Top 20)

Lum KJ, Sundaram R, Buck Louis GM, Louis TA. A Bayesian joint model of menstrual cycle length and fecundity. Biometrics. 2016;72(1):193-203. PMCID: PMC4761533. PMID: 26295923 (Top 20)

Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, Jensen TK, Jorgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A. Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility. Physiological Reviews. 2016; 96(1):55-97. PMCID: PMC4698396. PMID: 26582516 (Top 20)

Buck Louis GM, Grewal J, Albert PS, Sciscione A, Wing DA, Grobman WA, Newman RB, Wapner R, D’Alton ME, Skupski D, Nageotte MP, Ranzini AC, Owen J, Chien EK, Craigo S, Hediger ML, Kim S, Zhang C, Grantz KL. Racial/ethnic standards for fetal growth: The NICHD Fetal Growth Studies. American Journal of Obstetrics and Gynecology. 2015;213(4):449.e1–449.e41. PMCID: PMC4584427. PMID: 26410205 (Top 20)

*Schliep KC, Mumford SL, Peterson CM, Chen Z, Johnstone EB, Sharp HT, Stanford JB, Hammoud AO, Sun L, Buck Louis GM. Pain typology and incident endometriosis. Human Reproduction. 2015;30(10):2427-2438. PMCID: PMC4573450. PMID: 26269529 (Top 20)

Eisenberg ML, Chen Z, Ye A, Buck Louis GM. Relationship between physical occupational exposures and health on semen quality: Data from the LIFE Study. Fertility and Sterility. 2015;103(5):1271-1277. PMCID: PMC4417418. PMID: 25765658

Buck Louis GM, Chen Z, Schisterman EF, Kim S, Sweeney AM, Sundaram R, Lynch CD, Gore-Langton RE, Barr DB. Perfluorochemicals and Human Semen Quality: The LIFE Study. Environmental Health Perspectives. 2015;123(1):57-63. PMCID: PMC4286271. PMID: 25127343 (Top 20)

Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. Journal of Proteomics. 2015;113:194-205. PMCID: PMC4467531. PMID: 25284053

Eisenberg ML, Kim S, Chen Z, Sundaram R, Schisterman EF, Louis GM. The relationship between male BMI and waist circumference on semen quality: data from the LIFE Study. Human Reproduction. 2015;30(2):493-494. PMCID: PMC4303771. PMID: 25516559 (Top 20)

Pollack AZ, Buck Louis GM, Chen Z, Sun L, Trabert B, Guo Y, Kannan K. Bisphenol A, benzophenone-type UV filters, and phthalates in relation to uterine leiomyoma. Environmental Research. 2015;137:101-107. PMCID: PMC4355097. PMID: 25531814

Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck Louis GM, Hummelshoj L, Giudice LC, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA; WERF EPHect Working Group. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project (EPHect): II. Clinical and covariate phenotype data collection in endometriosis research. Fertility and Sterility. 2014;102(5):1223-1232. PMCID: PMC4252538. PMID: 25256930 (Top 20)

Buck Louis GM, Kannan K, Sapra KJ, Maisog J, Sundaram R. Urinary concentrations of benzophenone-type ultraviolet radiation filters and couples’ fecundity. American Journal of Epidemiology. 2014;180(12):1168-1175. PMCID: PMC4262441. PMID: 25395025

Zhang C, Sundaram R, Maisog J, Calafat AM, Barr DB, Buck Louis GM. A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes. Fertility and Sterility. 2014;103(1):184-189. PMCID: PMC4282598. PMID: 25450302 (Top 20)

Schisterman EF, Mumford SL, Browne RW, Barr DB, Chen Z, Buck Louis GM. Lipid concentrations and couple fecundity: The LIFE Study. Journal of Clinical Endocrinology and Metabolism. 2014;99(8):2786-2794. PMCID: PMC4121020. PMID: 24846535 (Top 20)

Lynch CD, Sundaram R, Maisog JM, Sweeney AM, Buck Louis GM. Preconception stress increases the risk of infertility: Results from a couple-based prospective cohort study – the LIFE Study. Human Reproduction. 2014;29(5):1067-1075. [Selected as the Human Reproduction Keynote lecture at the 2015 ESHRE Congress in Lisbon, Portugal, July 2015, in light of highest number of downloads within 6 months.] PMCID: PMC3984126. PMID: 24664130 (Top 20)

Buck Louis GM, Sundaram R, Sweeney AM, Schisterman EF, Maisog J, Kannan K. Urinary bisphenol A, phthalates, and couple fecundity: the LIFE Study. Fertility and Sterility. 2014;101(5):1359-1366. PMCID: PMC4008721. PMID: 24534276

Eisenberg ML, Kim S, Chen Z, Sundaram R, Schisterman EF, Buck Louis GM. The relationship between male BMI and waist circumference on semen quality: Data from the LIFE Study. Human Reproduction. 2014;29(2):193-200. PMCID: PMC3896223. PMID: 24306102 (Top 20)

Buck Louis GM, Sundaram R, Schisterman EF, Sweeney A, Lynch CD, Kim S, Maisog JM, Gore-Langton R, Eisenberg ML, Chen Z. Semen quality and time-to-pregnancy, the LIFE Study. Fertility and Sterility. 2014;101(2):453-462. PMCID: PMC3946620. PMID: 24239161 (Top 20)

*Pollack AZ, Buck Louis GM, Chen Z, Peterson CM, Sundaram R, Croughan MS, Sun L, Hediger ML, Stanford JB, Varner MW, Palmer CD, Steuerwald AJ, Parsons PJ. Trace elements and endometriosis: The ENDO Study. Reproductive Toxicology. 2013;42:41-48. PMCID: PMC3836840. PMID: 23892002

*Louis JF, Thoma ME, Sorensen DN, McLain AC, King RB, Sundaram R, Keiding N, Buck Louis GM.  The prevalence of couple infertility in the United States from a male perspective: Evidence from a nationally-representative sample. Andrology. 2013;1(5):741-748. PMCID: PMC3752331. PMID: 23843214 (Top 20)

Buck Louis GM, Peterson CM, Chen Z, Croughan M, Sundaram R, Stanford J, Varner MW, Kennedy A, Giudice L, Fujimoto VY, Sun L, Wang L, Guo Y, Kannan K. Bisphenol A and phthalates and endometriosis, The ENDO Study. Fertility and Sterility. 2013;100(1):162-169.e1-2. PMCID: PMC3700684. PMID: 23579005

Peterson CM, Johnstone EB, Hammoud AO, Stanford JB, Varner MW, Kennedy A, Chen Z, Sun L, Fujimoto VY, Hedinger ML, Buck Louis GM; ENDO Study Working Group. Risk factors associated with endometriosis: Importance of study population for characterizing disease in the ENDO Study. American Journal of Obstetrics and Gynecology. 2013;208(6):e1-11. PMCID: PMC4114145. PMID: 23454253

Buck Louis GM, Yeung E, Sundaram R, Laughon SK, Zhang C. The exposome – exciting opportunities for discoveries in reproductive and perinatal epidemiology. Paediatric and Perinatal Epidemiology. 2013;27(3):229-236. PMCID: PMC3625972. PMID: 23574410

Buck Louis GM, Sundaram R, Schisterman EF, Sweeney AM, Lynch CD, Gore-Langton RE, Maisog J, Kim S, Chen Z, Barr DB. Persistent environmental pollutants and couple fecundity: The LIFE Study. Environmental Health Perspectives. 2013;121(2):231-236. PMCID: PMC3569685. PMID: 23151773 (Top 20)

*Thoma ME, McLain AC, Louis JF, King RB, Trumble AC, Sundaram R, Buck Louis GM. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertility and Sterility. 2013;99(5):1324-1331.e1. PMCID: PMC3615032. PMID: 23290741 (Top 20)

Buck Louis GM and Sundaram R. Exposome: Time for Transformative Research. Statistics and Medicine. 2012;31(22):2569-2575. PMCID: PMC3842164. PMID: 22969025

Kunisue T, Chen Z, Buck Louis GM, Sundaram R, Hediger ML, Sun L, Kannan K. Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. Environmental Science and Technology. 2012;46(8):4624-4632. PMCID: PMC3352028. PMID: 22417702

Buck Louis GM, Chen Z, Peterson CM, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Varner MW, Fujimoto VY, Giudice LC, Trumble A, Parsons PJ, Kannan K. Persistent lipophilic environmental chemicals and endometriosis: The ENDO Study. Environmental Health Perspectives. 2012;120(6):811-816. PMCID: PMC3385438. PMID: 22417635 (Top 20)

Buck Louis GM, Sundaram R, Schisterman EF, Sweeney AM, Lynch CD, Gore-Langton RE, Chen Z, Kim S, Caldwell KL, Boyd DB. Heavy metals and couple fecundity, the LIFE Study. Chemosphere. 2012; 87:1201-1207. PMCID: PMC3327819. PMID: 22309709 (Top 20)

Honors & Awards

NICHD Collaboration Award, 2017, Eunice Kennedy Shriver National Institute of Child Health & Human Development

Society for Pediatric & Perinatal Research President’s Inaugural Award, 2014, Society for Pediatric & Perinatal Research

NIH Mentoring Award, 2004, National Institutes of Health

Service Award, 2000, International Society for Environmental Epidemiology

Abraham Lilienfeld Award, 1987, Society for Epidemiologic Research